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According to the 2015 Cochrane systematic review, atorvastatin showed greater cholesterol-lowering effect in women than in men compared to rosuvastatin. [49] In children, statins are effective at reducing cholesterol levels in those with familial hypercholesterolemia. [50] Their long term safety is, however, unclear.
Most efficacious in lowering LDL-C levels, statins block the action of HMG-CoA reductase through competitive inhibition. [18] HMG-CoA reductase, an enzyme found in hepatocytes, is responsible for the conversion of HMG-CoA to mevalonic acid for cholesterol biosynthesis. Inhibition of this enzyme reduces the synthesis and thus, availability of ...
Many lifestyle changes can help lower cholesterol. Even so, sometimes you might need to take medications as well. 10 Ways to Naturally Lower Cholesterol, According to Doctors
The trial analyzed 17,802 patients without evidence of heart disease but with high CRP levels. In 2008, results presented at the American Heart Association meeting and published in the New England Journal of Medicine (NEJM) found that patients with low-to-normal LDL cholesterol receiving rosuvastatin had a lower rate of major cardiovascular events.
Using PREVENT to calculate the 10-year risk for developing heart disease, the researchers determined that some 40% fewer people would have met the criteria for a statin prescription.
Cholesterol-lowering medications such as statins are recommended for both men and women with coronary artery disease. They can help reduce symptoms and prevent heart attacks and death.
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