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The Fick principle states that blood flow to an organ can be calculated using a marker substance if the following information is known: Amount of marker substance taken up by the organ per unit time; Concentration of marker substance in arterial blood supplying the organ; Concentration of marker substance in venous blood leaving the organ
Arterial input function (AIF), also known as a plasma input function, refers to the concentration of tracer in blood-plasma in an artery measured over time. The oldest record on PubMed shows that AIF was used by Harvey et al. [1] in 1962 to measure the exchange of materials between red blood cells and blood plasma, and by other researchers in 1983 for positron emission tomography (PET) studies.
The modified Allen's test is also performed prior to heart bypass surgery. The radial artery is occasionally used as a conduit for bypass surgery, and its patency lasts longer in comparison to the saphenous veins. Prior to heart bypass surgery, the test is performed to assess the suitability of the radial artery to be used as a conduit.
The pumping action of the heart generates pulsatile blood flow, which is conducted into the arteries, across the micro-circulation and eventually, back via the venous system to the heart. During each heartbeat, systemic arterial blood pressure varies between a maximum and a minimum pressure. [33]
Blood flow is one the most important factors affecting the delivery of oxygen and other nutrients to tissues. Abnormal blood flow is associated with many diseases such as stroke and cancer. Tumors from cancer can generate abnormal tumor blood flow compared to the surrounding tissue. Current treatments attempt to decrease blood flow to cancer cells.
Arterial spin labelling (ASL): Magnetic labeling of arterial blood below the imaging slab, without the need of gadolinium contrast [4] It can also be argued that diffusion MRI models, such as intravoxel incoherent motion , also attempt to capture perfusion.
Coronary flow reserve is used in diagnostics and treatment of patients with conditions such as coronary artery disease and syndrome X. [7] In the treatment of these conditions, vasodilators are used to allow sufficient blood to flow past a stenosis, for example, and the measurement of CFR enables the efficacy of such interventions to be measured.
Atomic diffusion in polycrystalline materials is therefore often modeled using an effective diffusion coefficient, which is a combination of lattice, and grain boundary diffusion coefficients. In general, surface diffusion occurs much faster than grain boundary diffusion, and grain boundary diffusion occurs much faster than lattice diffusion.
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