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Zinc protoporphyrin (ZPP) refers to coordination complexes of zinc and protoporphyrin IX. It is a red-purple solid that is soluble in water. It is a red-purple solid that is soluble in water. The complex and related species are found in red blood cells when heme production is inhibited by lead and/or by lack of iron .
Erythropoietic protoporphyria (or commonly called EPP) is a form of porphyria, which varies in severity and can be very painful.It arises from a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the red blood cells (erythrocytes), plasma, skin, and liver. [2]
Protoporphyrin ferrochelatase (EC 4.98.1.1, formerly EC 4.99.1.1, or ferrochelatase; systematic name protoheme ferro-lyase (protoporphyrin-forming)) is an enzyme encoded by the FECH gene in humans. [1] Ferrochelatase catalyses the eighth and terminal step in the biosynthesis of heme, converting protoporphyrin IX into heme B. It catalyses the ...
Derivatives of protoporphyrin IX are common in nature, the precursor to hemes. Octaethylporphyrin (H 2 OEP) is a synthetic analogue of protoporphyrin IX. Unlike the natural porphyrin ligands, OEP 2− is highly symmetrical.
In blood plasma, zinc is bound to and transported by albumin (60%, low-affinity) and transferrin (10%). [10] Because transferrin also transports iron, excessive iron reduces zinc absorption, and vice versa. A similar antagonism exists with copper. [30] The concentration of zinc in blood plasma stays relatively constant regardless of zinc intake ...
The underlying mechanism results in a decrease in the amount of heme produced and a build-up of substances involved in making heme. [1] Porphyrias may also be classified by whether the liver or bone marrow is affected. [1] Diagnosis is typically made by blood, urine, and stool tests. [2] Genetic testing may be done to determine the specific ...
Zinc is a key mineral that helps our immune system and cell reproduction. Here's what you need to know about the mineral, and where it comes from. This Is What Zinc Does to Your Body
Protoporphyrin IX is an organic compound, classified as a porphyrin, that plays an important role in living organisms as a precursor to other critical compounds like heme and chlorophyll. It is a deeply colored solid that is not soluble in water.