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These are caused by a missense mutation in the alpha chain that leads to permanent blindness. A challenge to the use of CRISPR in eye disease is that retinal tissue in the eye is free from body immune response. Researchers' approach for using CRISPR is to bag the gene coding retinal protein and edit the genome. [205]
On 26 November 2018, The CRISPR Journal published ahead of print an article by He, Ryan Ferrell, Chen Yuanlin, Qin Jinzhou, and Chen Yangran in which the authors justified the ethical use of CRISPR gene editing in humans. [74] As the news of CRISPR babies broke out, the editors reexamined the paper and retracted it on 28 December, announcing:
A denture cleaner (also termed denture cleanser) is used to clean dentures when they are out of the mouth. The main use is to control the growth of microorganisms on the dentures, especially Candida albicans, thereby preventing denture-related stomatitis. When dentures are worn in the mouth, a biofilm develops which may be similar to dental plaque.
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In addition to brushing, cleaning between teeth may help to prevent build-up of plaque bacteria on the teeth. This may be done with dental floss or interdental brushes.. 80% of cavities occur in the grooves, or pits and fissures, of the chewing surfaces of the teeth, [4] however, there is no evidence currently showing that normal at-home flossing reduces the risk of cavities in these areas.
Dental tape is used for polishing the proximal surfaces of teeth that are inaccessible to other polishing instruments. It is also used with polishing paste. Particular care should be taken to avoid injury to the gingiva. The area should be cleaned with warm water to remove all remnants of the paste.
Cas9 (or "CRISPR-associated protein 9") is an enzyme that uses CRISPR sequences as a guide to recognize and open up specific strands of DNA that are complementary to the CRISPR sequence. Cas9 enzymes together with CRISPR sequences form the basis of a technology known as CRISPR-Cas9 that can be used to edit genes within living organisms.