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Bone marrow suppression is a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine. [2] The risk is especially high in cytotoxic chemotherapy for leukemia. In the case of non-small-cell lung cancer, myelosuppression predisposition was shown to be modulated by enhancer mutations. [3]
Nausea and vomiting are two of the most feared cancer treatment-related side-effects for people with cancer and their families. In 1983, Coates et al. found that people receiving chemotherapy ranked nausea and vomiting as the first and second most severe side-effects, respectively. [ 98 ]
Some of the hazards and side effects that were formerly linked to larger dosages of chemotherapy medications have been lessened thanks to these improvements. Severe suppression of the bone marrow , heightened vulnerability to infections , gastrointestinal toxicity , and more systemic problems were among the possible side effects.
Epidemiologists have found evidence to suggest that long-term, high-dose supplementation with B6 and B12 may increase risk of developing lung cancer.
Side effects of ABVD can be divided into acute (those occurring while receiving chemotherapy) and delayed (those occurring months to years after completion of chemotherapy). Delayed side effects have assumed particular importance because many patients treated for Hodgkin lymphoma are cured and can expect long lives after completion of chemotherapy.
Since chemotherapy affects the whole body, it can have a wide range of side effects. Patients often find that they start losing their hair since the drugs that are combatting the cancer cells also attack the cells in the hair roots. This powerful treatment can also lead to fatigue, loss of appetite, and vomiting depending on the person. [11]
Common side effects include nausea and bone marrow suppression. [7] Other severe side effects may include anaphylaxis and the development of other cancers. [7] Use during pregnancy may result in harm to the fetus. [8] Melphalan belongs to the class of nitrogen mustard alkylating agents. [7] It works by interfering with the creation of DNA and ...
Gemcitabine is a chemotherapy drug that works by killing any cells that are dividing. [11] Cancer cells divide rapidly and so are targeted at higher rates by gemcitabine, but many essential cells also divide rapidly, including cells in skin, the scalp, the stomach lining, and bone marrow, resulting in adverse effects. [17]: 265