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[14] [15] Epinephrine does this through its effects on alpha and beta receptors. [15] It is found in many animals and some single-celled organisms, [16] [17] but the medication is produced synthetically and is not harvested from animals. [18] Jōkichi Takamine first isolated epinephrine in 1901, and it came into medical use in 1905.
The first modern epinephrine autoinjector, the EpiPen, was invented in the mid-1970s at Survival Technology in Bethesda, Maryland, US by Sheldon Kaplan [11] [12] and was first approved for marketing by the FDA in 1987. [13] One of the people who helped in making the EpiPen was Richard B. Toren.
Adrenaline, also known as epinephrine, is a hormone and medication [10] [11] which is involved in regulating visceral functions (e.g., respiration). [10] [12] It appears as a white microcrystalline granule. [13]
Pfizer’s EpiPens may have set consumers back $600, but it’s now costing the drugmaker a whole lot more. Pfizer has agreed to pay $345 million to resolve claims by consumers who alleged they ...
The Four Thieves Vinegar Collective is an anarchist biohacking group founded in 2015 by Michael Laufer.They have published instructions for the "EpiPencil", an epinephrine autoinjector, and the "Apothecary MicroLab", a do-it-yourself (DIY) device intended to make a variety of medications, most notably pyrimethamine (Daraprim).
An injector pen consists of a chamber or cartridge of medication, a tip to attach a needle, and a piston or plunger to inject the dose. [4] Some pens, including most insulin pens, include dials to adjust the dose of the injection before each administration. [2]
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Christopher Wren performed the earliest confirmed experiments with crude hypodermic needles, performing intravenous injection into dogs in 1656. [7] These experiments consisted of using animal bladders (as the syringe) and goose quills (as the needle) to administer drugs such as opium intravenously to dogs. Wren and others' main interest was to ...