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Many benzodiazepines (including midazolam) have longer half-lives than flumazenil. Therefore, in cases of overdose, repeated doses of flumazenil may be required to prevent recurrent symptoms once the initial dose of flumazenil wears off. [citation needed] It is hepatically metabolised to inactive compounds which are excreted in the urine.
The antidote for an overdose of midazolam (or any other benzodiazepine) is flumazenil. [41] While effective in reversing the effects of benzodiazepines it is not used in most cases as it may trigger seizures in mixed overdoses and benzodiazepine dependent individuals. [60] [61] Symptoms of midazolam overdose can include: [60] [61]
[172] [173] The symptoms of a benzodiazepine overdose may include; drowsiness, slurred speech, nystagmus, hypotension, ataxia, coma, respiratory depression, and cardiorespiratory arrest. [170] A reversal agent for benzodiazepines exists, flumazenil (Anexate), itself belonging to the
EXTON, Pa. (AP) - A Pennsylvania veterinarian has used an overdose reversal drug to save a kitten that had been given heroin. Police said Tuesday they arrested the suburban Philadelphia man who ...
Opioid overdose reversal drug naloxone may be safe and effective for over-the-counter use in some forms, the U.S. Food and Drug Administration (FDA) said on Tuesday, potentially paving the way for ...
The approval of the drug, called RiVive, will provide patients with another over-the-counter option in the United States, where drug-related overdose deaths surpassed 100,000 in 2021.
On 21 April 2016, American author and journalist Michelle McNamara died from an accidental overdose; medical examiners determined fentanyl was a contributing factor. [224] [225] On 11 November 2016, Canadian video game composer Saki Kaskas died of a fentanyl overdose; [226] he had been battling heroin addiction for over a decade. [226]
The Oregon Health Authority plans to offer free opioid overdose reversal kits to middle and high schools throughout the state, the agency said Tuesday.