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sn-Glycerol 3-phosphate [a] [b] is the organic ion with the formula HOCH 2 CH(OH)CH 2 OPO 3 2-. It is one of two stereoisomers of the ester of dibasic phosphoric acid (HOPO 3 2- ) and glycerol . It is a component of bacterial and eukaryotic glycerophospholipids . [ 2 ]
When dihydroxyacetone phosphate is produced, glyceroneogenesis will branch off from gluconeogenesis. [1] With the expense of NADH, dihydroxyacetone phosphate will convert to glycerol 3-phosphate, which is the final product of glyceroneogenesis. In addition, triglyceride can be generated by re-esterifying 3 fatty acid chains on glycerol 3-phosphate.
The glycerol also enters the bloodstream and is absorbed by the liver or kidney where it is converted to glycerol 3-phosphate by the enzyme glycerol kinase. Hepatic glycerol 3-phosphate is converted mostly into dihydroxyacetonephosphate (DHAP) and then glyceraldehyde 3-phosphate (GA3P) to rejoin the glycolysis and gluconeogenesis pathway. [15]
Glycerol-3-phosphate dehydrogenase (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate (a.k.a. glycerone phosphate, outdated) to sn-glycerol 3-phosphate. [2] Glycerol-3-phosphate dehydrogenase serves as a major link between carbohydrate metabolism and lipid metabolism.
In enzymology, a glycerol-3-phosphate-glucose phosphotransferase (EC 2.7.1.142) is an enzyme that catalyzes the chemical reaction sn-glycerol 3-phosphate + D-glucose ⇌ {\displaystyle \rightleftharpoons } glycerol + D-glucose 6-phosphate
The DHAP formed during fructolysis can also be converted to glycerol and then glycerol 3-phosphate for TG synthesis. Thus, fructose can provide trioses for both the glycerol 3-phosphate backbone, as well as the free fatty acids in TG synthesis. Indeed, fructose may provide the bulk of the carbohydrate directed toward de novo TG synthesis in ...
In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat. [1] Lipogenesis encompasses both fatty acid and triglyceride synthesis , with the latter being the process by which fatty acids are esterified to glycerol before ...
The glycerol phosphate shuttle was first characterized as a major route of mitochondrial hydride transport in the flight muscles of blow flies. [5] [6] It was initially believed that the system would be inactive in mammals due to the predominance of lactate dehydrogenase activity over glycerol-3-phosphate dehydrogenase 1 (GPD1) [5] [7] until high GPD1 and GPD2 activity were demonstrated in ...