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Deamination is the removal of an amino group from a molecule. [1] Enzymes that catalyse this reaction are called deaminases. In the human body, deamination takes place primarily in the liver; however, it can also occur in the kidney. In situations of excess protein intake, deamination is used to break down amino acids for energy.
One example of this is a study conducted by D. Fattori looking at the regioselectivity of the Demjanov rearrangement in one-carbon enlargements of naked sugars. It showed that when an exo methylamine underwent Demjanov nitrous acid deamination, ring enlargement was not produced.
The APOBEC family of proteins perform mRNA modifications by deaminating cytidine bases to uracil. The N-terminal domain of APOBEC-like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalytic domain. More specifically, the catalytic domain is a zinc dependent cytidine deaminase domain and is essential for cytidine ...
Asn-Gly (NG),is the most flexible and since it is acidic, it is most prone to deamidation with a half-life around 24 h under physiological conditions (pH 7.4, 37 °C). [3] As a free amino acid, or as the N-terminal residue of a peptide or protein, glutamine deamidates readily to form pyroglutamic acid (5-oxoproline). The reaction proceeds via ...
11628 Ensembl ENSG00000111732 ENSMUSG00000040627 UniProt Q9GZX7 Q9WVE0 RefSeq (mRNA) NM_020661 NM_001330343 NM_009645 RefSeq (protein) NP_001317272 NP_065712 NP_033775 Location (UCSC) Chr 12: 8.6 – 8.61 Mb Chr 6: 122.53 – 122.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Activation-induced cytidine deaminase, also known as AICDA, AID and single-stranded DNA cytosine ...
Cytosine (/ ˈ s aɪ t ə ˌ s iː n,-ˌ z iː n,-ˌ s ɪ n / [2] [3]) (symbol C or Cyt) is one of the four nucleotide bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA). It is a pyrimidine derivative, with a heterocyclic aromatic ring and two substituents attached (an amine group at position 4 and a keto group ...
This page will attempt to list examples in mathematics. To qualify for inclusion, an article should be about a mathematical object with a fair amount of concreteness. Usually a definition of an abstract concept, a theorem, or a proof would not be an "example" as the term should be understood here (an elegant proof of an isolated but particularly striking fact, as opposed to a proof of a ...
Examples of mismatched bases include a G/T or A/C pairing (see DNA repair). Mismatches are commonly due to tautomerization of bases during DNA replication. The damage is repaired by recognition of the deformity caused by the mismatch, determining the template and non-template strand, and excising the wrongly incorporated base and replacing it ...