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Theophylline, also known as 1,3-dimethylxanthine, is a drug that inhibits phosphodiesterase and blocks adenosine receptors. [1] It is used to treat chronic obstructive pulmonary disease (COPD) and asthma . [ 2 ]
It is a combination drug containing three active ingredients - theophylline, ephedrine, phenobarbital. [2] This medication relaxes the smooth muscle of the airways, making breathing easier. [ 3 ] The common side effects of Tedral include gastrointestinal disturbances , dizziness , headache and lightheadedness .
The effects of theophylline/ephedrine as a performance-enhancing drug in exercise and sports have been studied. [20] [21] Use of theophylline/ephedrine combinations has led to disqualification of elite athletes due to ephedrine being banned in competitive sports. [22]
Zileuton is a minor substrate of CYP1A2, 2C8/9, 3A4, and a weak inhibitor of CYP 1A2. The drug has been shown to increase the serum concentration or effects of theophylline, propranolol, and warfarin, although significant increase in prothrombin time is not obvious. It is advised that the doses of each medication be monitored and/or reduced ...
Viloxazine increased plasma levels of phenytoin by an average of 37%. [21] It also was known to significantly increase plasma levels of theophylline and decrease its clearance from the body, [ 22 ] sometimes resulting in accidental overdose of theophylline .
Medications like diuretics and antidepressants can increase the blood pressure-lowering effects of minoxidil. However, interactions are more likely with oral minoxidil than topical minoxidil.
More severe effects, such as pulmonary edema, myocardial ischemia, and cardiac arrhythmia, are exceptional.) [6] [7] [1] Overuse of β 2 agonists and asthma treatment without proper inhaled corticosteroid use has been associated with an increased risk of asthma exacerbations and asthma-related hospitalizations. [ 8 ]
Isoniazid may increase the amount of phenytoin in the body. The doses of phenytoin may need to be adjusted when given with isoniazid. [40] [41] Isoniazid may increase the plasma levels of theophylline. There are some cases of theophylline slowing down isoniazid elimination. Both theophylline and isoniazid levels should be monitored. [42]
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related to: drugs that increase theophylline levels in blood count affect- 109 S High St #100, Columbus, OH · Directions · (614) 224-4261
