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Sucralfate is a locally acting substance that in an acidic environment (pH < 4) reacts with hydrochloric acid in the stomach to form a cross-linking, viscous, paste-like material capable of acting as an acid buffer for as long as 6 to 8 hours after a single dose. [29]
Sucralfate is a mucosal coating agent, composed of an aluminum salt of sulfated sucrose. [97] It is not recommended for use in the prevention of oral mucositis in head and neck cancer patients receiving radiotherapy or chemoradiation , due to a lack of efficacy found in a well-designed, randomized controlled trial .
[9] [10] In contrast, RAVE and chronic radiation proctopathy usually is not self-limited and often requires additional therapies. [4] These include sucralfate, hyperbaric oxygen therapy, corticosteroids, metronidazole, argon plasma coagulation, radiofrequency ablation and formalin irrigation.
English: Skeletal formula of sucralfate—a cytoprotective medication used in the treatment of GERD, gastritis, peptic ulcer disease, stress ulcers and dyspepsia. Date 22 September 2023
Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Sucralfate. PubMed provides review articles from the past five years (limit to free review articles)
From Wikipedia, the free encyclopedia. ... Sucralfate; From or to a drug trade name: This is a redirect from (or to) the trade name of a drug to (or from) ...
Prostaglandin analogues such as misoprostol are used in treatment of duodenal and gastric ulcers. [2] Misoprostol and other prostaglandin analogues protect the lining of the gastrointestinal tract from harmful stomach acid and are especially indicated for the elderly on continuous doses of NSAIDs.
[10] Gastritis is believed to affect about half of people worldwide. [4] In 2013 there were approximately 90 million new cases of the condition. [11] As people get older the disease becomes more common. [4] It, along with a similar condition in the first part of the intestines known as duodenitis, resulted in 50,000 deaths in 2015. [5]