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Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
PDE5 inhibitor drugs are effective in men regardless of why they have erectile dysfunction — including vascular disease, nerve problems, and even psychological causes. [ citation needed ] PDE5-inhibiting drugs can cause a number of side-effects , including headache , lightheadedness, dizziness , flushing, nasal congestion, and changes in vision .
The PDE5 inhibitors sildenafil, vardenafil and tadalafil are competitive and reversible inhibitors of cGMP hydrolysis by the catalytic side of PDE5. The structures of vardenafil and sildenafil are similar, they both contain similar structured purine ring of cGMP that contributes their features to act as a competitive inhibitor of PDE5.
Like other ED medications, Cialis is a PDE5 inhibitor. It works by blocking the effects of PDE5, or cGMP-specific phosphodiesterase type 5 — an enzyme that’s responsible for controlling the ...
As the name suggests, PDE5 inhibitors inhibit PDE5, which degrades cGMP. So when you take Viagra, cGMP builds up in the smooth muscle and is free to do its thing — which is to dilate blood ...
Tadalafil works by inhibiting the effects of cGMP-specific phosphodiesterase type 5 (or PDE5) — an enzyme found in the smooth muscle cells of blood vessels. ... The prescription drug is a PDE5 ...
Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).
Phosphodiesterase inhibitors prevent the degradation of cGMP, thereby enhancing and/or prolonging its effects. For example, Sildenafil (Viagra) and similar drugs enhance the vasodilatory effects of cGMP within the corpus cavernosum by inhibiting PDE 5 (or PDE V).
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