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The hallmark symptom of LATE is a progressive memory loss that predominantly affects short-term and episodic memory. [1] This impairment is often severe enough to interfere with daily functioning and usually remains the chief neurologic deficit, unlike other types of dementia in which non-memory cognitive domains and behavioral changes might be noted earlier or more prominently. [1]
The hippocampus (pl.: hippocampi; via Latin from Greek ἱππόκαμπος, 'seahorse'), also hippocampus proper, is a major component of the brain of humans and many other vertebrates. In the human brain the hippocampus, the dentate gyrus, and the subiculum are the components of the hippocampal formation located in the limbic system.
Older adults can exhibit reduced activity in specific brain regions during cognitive tasks, particularly in medial temporal areas related to memory processing. On the other hand, overrecruitment of other brain areas, mainly in the prefrontal cortex, can be engaged in memory-related tasks. [ 10 ]
The “spacing effect” refers to a phenomenon whereby learning, or the creation of a memory, occurs more effectively when information, or exposure to a stimulus, is spaced out.
The researchers looked at 181 potential risk factors, and then estimated how likely they are to predict dementia and cognitive impairment for people two, four, and 20 years after they turn 60.
The hippocampus' right side is more oriented towards responding to spatial aspects, whereas the left side is associated with other context information. Also, there is evidence that experience in building extensive mental maps, such as driving a city taxi for a long time (since this requires considerable memorization of routes), can increase the ...
The brain plays a big part in the aging process, and scientists think they’ve pinpointed the specific cells that control it.. In a study of mice, researchers at the Allen Institute identified ...
These various changes have attempted to be mapped by conceptual models like the Scaffolding Theory of Aging and Cognition (STAC) in 2009. The STAC model looks at factors like neural changes to the white matter, dopamine depletion, shrinkage, and cortical thinning. [5] CT scans have found that the cerebral ventricles expand as a function of age.