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[110] [191] Blockade of androgen signaling in the breast disinhibits the actions of estrogens in this tissue. [192] Although useful as an antiandrogen in women, who have low testosterone levels compared to men, [193] [194] spironolactone is described as having relatively weak antiandrogenic activity. [195] [191] [196] [197]
A 1991 review reported that the influences of spironolactone on androgen levels in women were variable and inconsistent. [78] Spironolactone has shown no significant effect on levels of testosterone, estradiol, luteinizing hormone, and follicle-stimulating hormone in men. [146] [78]
Hyperandrogenism is a medical condition characterized by high levels of androgens.It is more common in women than men. [4] Symptoms of hyperandrogenism may include acne, seborrhea, hair loss on the scalp, increased body or facial hair, and infrequent or absent menstruation.
Conversely, “with too much testosterone, women often have acne, too much hair on the body, hair loss on the head, high blood pressure, elevated cholesterol, skipped cycles, or problems ...
Spironolactone stops androgen from binding to receptors, which reduces testosterone and DHT levels and decreases hair loss. Women who are pregnant or trying to get pregnant shouldn’t take ...
In addition to hypersecretion of cortisol, excess androgens are secreted. [8] In females, increased secretion of androgens, such as testosterone, results in masculinization which may present as facial hair growth and a deepened voice. [2] Treatment for Cushing's syndrome aims to reduce the high levels of cortisol circulating through the human body.
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