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DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity to A 2 adenosine receptors, in contrast to the A 1 subtype receptors. [1] DMPX had 28× and 15× higher potency than caffeine in blocking peripheral and central NECA-responses. The locomotor stimulation caused by DMPX (ED 50 10 μmol/kg) was similarly higher ...
Drugs that interact usually share three common features: they are taken orally, normally only a small amount enters systemic blood circulation, and they are metabolized by CYP3A4. [1] The effects on the CYP3A4 in the liver could, in principle, cause interactions with non-oral drugs, [citation needed] and non-CYP3A4-mediated effects also exist. [31]
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds:
Recent research reveals that caffeine has health benefits for most moderate coffee drinkers. Here are the pros and cons of drinking certain coffees, with expert insights and advice.
This is a partial list of herbs and herbal treatments with known or suspected adverse effects, either alone or in interaction with other herbs or drugs.Non-inclusion of an herb in this list does not imply that it is free of adverse effects.
Caffeine can cause a physical dependence, if consumed in excessive amounts. [3] The need for caffeine can be identified when individuals feel headaches, fatigue and muscle pain 24 hours after their last energy drink. [4] Some commercially distributed drinks contain guarana, a South American berry with a caffeine content about twice that of ...
"Indiana University Department of Medicine Clinical Pharmacology Drug Interactions Flockhart Table ™". "INHIBITORS, INDUCERS AND SUBSTRATES OF CYTOCHROME P450 ISOZYMES". "The Life Raft Group: Long List of Inhibitors and Inducers of CYP3A4 and CYP2D6". "DRUGBANK Online: Cytochrome P-450 Enzyme Inhibitors".
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