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This is due to a more than 90% conversion of testosterone into DHT in the prostate via locally expressed 5α-reductase. [7] Because of this, and because DHT is much more potent as an androgen receptor agonist than testosterone, [47] DHT is the major androgen in the prostate gland. [7]
This is the mechanism of 5α-reductase on testosterone to convert it into DHT (dihydrotestosterone). 5α-Reductase works by using the reducing power of NADPH to perform a hydride shift on the double carbon bond in the ring causing enolate formation and subsequent tautamerization to form DHT. [13]
Normally, this pathway is not very active in healthy adult males, as the majority of DHT is produced through the classical pathway, which involves the direct conversion of T into DHT by one of the SRD5A isozymes. However, when T levels are reduced through ADT, the body may compensate by increasing the production of P4, which can then serve as a ...
Researchers believe that men affected by androgenetic alopecia tend to have higher levels of the 5-alpha-reductase enzyme, which converts testosterone into DHT, as well as an increased level of ...
It’s created as a byproduct of the sex hormone testosterone, meaning your body regularly converts a small amount of the testosterone you create into DHT. This conversion happens thanks to an ...
By blocking the conversion of testosterone to DHT, finasteride treatment drastically reduces DHT levels in the body. ... Since testosterone is an important hormone for desire and function, this ...
The conversion of testosterone into DHT is an important factor in the etiology of a variety of androgen-dependent conditions, including acne, excessive facial/body hair growth, scalp hair loss, prostate enlargement, and prostate cancer. [1]
Androstanedione is formed from androstenedione by 5α-reductase and from DHT by 17β-hydroxysteroid dehydrogenase. [2] [3] It has some androgenic activity. [4] In female genital skin, the conversion of androstenedione into DHT through 5α-androstanedione appears to be more important than the direct conversion of testosterone into DHT. [5]