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Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone or stanolone) is an endogenous androgen sex steroid and hormone primarily involved in the growth and repair of the prostate and the penis, as well as the production of sebum and body hair composition.
Plus, DHT also shortens the anagen (growth) phase of the hair growth cycle, which means the hair isn’t given as much opportunity to grow, so the length of each hair shaft is reduced.
The pathway from progesterone (P4) to DHT is similar to that described above from 17OHP to DHT, but the initial substrate for 5α-reductase is P4 rather than 17OHP. Placental P4 in the male fetus is the feedstock, that is, a starting point, the initial substrate, for the backdoor pathway found operating in multiple non-gonadal tissues.
In BPH, DHT acts as a potent cellular androgen and promotes prostate growth; therefore, DHT blockers inhibit and alleviate symptoms of BPH. In alopecia, male and female-pattern baldness is an effect of androgenic receptor activation, so reducing levels of DHT also reduces hair loss.
How Does Stress Cause Hair Loss? For many women, hair loss does have a hereditary component and is influenced by hormonal and genetic factors — like sensitivity to dihydrotestosterone ( DHT ).
When it comes to hair loss, DHT binds to receptors in the scalp and causes hair follicle miniaturization. This means it shortens the anagen phase (or growth phase) of the hair growth cycle.
Androsterone is a metabolite of testosterone and dihydrotestosterone (DHT). In addition, it can be converted back into DHT via 3α-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase , bypassing conventional intermediates such as androstanedione and testosterone, and as such, can be considered to be a metabolic intermediate in ...
Finasteride Blocks DHT to Stop Hair Loss. Finasteride is one of two 5-alpha reductase inhibitors, along with dutasteride. 5-alpha reductase is an enzyme that your body eventually converts into a ...
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