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  2. Matrix-assisted laser desorption/ionization - Wikipedia

    en.wikipedia.org/wiki/Matrix-assisted_laser_de...

    MALDI TOF mass spectrometer. In mass spectrometry, matrix-assisted laser desorption/ionization (MALDI) is an ionization technique that uses a laser energy-absorbing matrix to create ions from large molecules with minimal fragmentation. [1]

  3. Time-of-flight mass spectrometry - Wikipedia

    en.wikipedia.org/wiki/Time-of-flight_mass...

    Mass resolution can be improved in axial MALDI-TOF mass spectrometer where ion production takes place in vacuum by allowing the initial burst of ions and neutrals produced by the laser pulse to equilibrate and to let the ions travel some distance perpendicularly to the sample plate before the ions can be accelerated into the flight tube. The ...

  4. MALDI imaging - Wikipedia

    en.wikipedia.org/wiki/MALDI_imaging

    MALDI mass spectrometry imaging (MALDI-MSI) is the use of matrix-assisted laser desorption ionization as a mass spectrometry imaging [2] technique in which the sample, often a thin tissue section, is moved in two dimensions while the mass spectrum is recorded. [3]

  5. Mass spectrometry - Wikipedia

    en.wikipedia.org/wiki/Mass_spectrometry

    Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. ... One example is MALDI-TOF, ...

  6. Peptide mass fingerprinting - Wikipedia

    en.wikipedia.org/wiki/Peptide_mass_fingerprinting

    A typical workflow of a peptide mass fingerprinting experiment. Peptide mass fingerprinting (PMF), also known as protein fingerprinting, is an analytical technique for protein identification in which the unknown protein of interest is first cleaved into smaller peptides, whose absolute masses can be accurately measured with a mass spectrometer such as MALDI-TOF or ESI-TOF. [1]

  7. List of mass spectrometry software - Wikipedia

    en.wikipedia.org/wiki/List_of_mass_spectrometry...

    Utility for proteomics designed to support the preprocessing and analysis of MALDI-TOF mass spectrometry data that loads data from mzML, mzXML and CSV files. It allows users to apply baseline correction, normalization, smoothing, peak detection and peak matching.

  8. Surface-enhanced laser desorption/ionization - Wikipedia

    en.wikipedia.org/wiki/Surface-enhanced_laser_de...

    In SEAC, the sample surface is modified to bind the analyte of interest for analysis with laser desorption/ionization mass spectrometry (LDI-MS). [ 1 ] [ 4 ] [ 6 ] SEPAR is a combination of SEND and SEAC; the modified sample surface also acts as an energy absorbing matrix for ionization.

  9. Delayed extraction - Wikipedia

    en.wikipedia.org/wiki/Delayed_extraction

    Delayed extraction is a method used with a time-of-flight mass spectrometer in which the accelerating voltage is applied after some short time delay following pulsed laser desorption/ionization from a flat surface of target plate or, in other implementation, pulsed electron ionization or Resonance enhanced multiphoton ionization in some narrow ...

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