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  2. Giant-cell glioblastoma - Wikipedia

    en.wikipedia.org/wiki/Giant-cell_glioblastoma

    The giant-cell glioblastoma is a histological variant of glioblastoma, presenting a prevalence of bizarre, multinucleated (more than 20 nuclei) giant (up to 400 μm diameter) cells. It occasionally shows an abundant stromal reticulin network and presents a high frequency of TP53 gene mutations .

  3. Giant-cell carcinoma of the lung - Wikipedia

    en.wikipedia.org/wiki/Giant-cell_carcinoma_of...

    Giant cell carcinoma of the lung; Pulmonary giant cell carcinoma represents a rare variety of non-small cell lung carcinoma that is characterized by the presence of numerous tumor giant cells and an influx of inflammatory cells that are mostly polymorphonuclear leukocytes admixed with macrophages.

  4. Giant cell - Wikipedia

    en.wikipedia.org/wiki/Giant_cell

    A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma. [ 1 ] Although there is typically a focus on the pathological aspects of multinucleate giant cells (MGCs), they also play many important physiological roles.

  5. Tenosynovial giant cell tumor - Wikipedia

    en.wikipedia.org/wiki/Tenosynovial_giant_cell_tumor

    Tenosynovial giant cell tumor (TGCT) is a non-malignant tumor defined histologically as inclusions of “osteoclast-like” multinucleated giant cells, hemosiderin, and macrophages. [1] This histology can present one of 2 clinically distinct ways. TGCT tumors often develop from the lining of joints (also known as synovial tissue).

  6. Giant-cell fibroblastoma - Wikipedia

    en.wikipedia.org/wiki/Giant-cell_fibroblastoma

    Giant cell fibroblastoma (GCF) is a rare type of soft-tissue tumor marked by painless nodules in the dermis (the inner layer of the two main layers of tissue that make up the skin) and subcutaneous (beneath the skin) tissue. These tumors may come back after surgery, but they do not spread to other parts of the body.

  7. Touton giant cell - Wikipedia

    en.wikipedia.org/wiki/Touton_giant_cell

    Further proof that these Touton giant cells are histiocytic in origin, meaning they arise from a macrophage-lineage cell, is the fact they react positively to enzymes found in histiocytes such as lysozyme, alpha 1-anti-trypsin and alpha 1-anti-chymotrypsin. Touton giant cells are able to express these proteins which are involved in actions such ...

  8. Giant-cell tumor of bone - Wikipedia

    en.wikipedia.org/wiki/Giant-cell_tumor_of_bone

    A number of tumors have giant cells, but are not true benign giant-cell tumors. These include aneurysmal bone cyst, chondroblastoma, simple bone cyst, osteoid osteoma, osteoblastoma, osteosarcoma, giant-cell reparative granuloma, Giant-cell tumor of the tendon sheath and brown tumor of hyperparathyroidism. [citation needed]

  9. Subependymal giant cell astrocytoma - Wikipedia

    en.wikipedia.org/wiki/Subependymal_giant_cell...

    Subependymal giant cell astrocytoma (SEGA, SGCA, or SGCT) is a low-grade astrocytic brain tumor (astrocytoma) that arises within the ventricles of the brain. [1] It is most commonly associated with tuberous sclerosis complex (TSC). Although it is a low-grade tumor, its location can potentially obstruct the ventricles and lead to hydrocephalus.

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