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In humans, the MSTN gene is located on the long (q) arm of chromosome 2 at position 32.2. [5] Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. [6] Myostatin is a myokine that is produced and released by myocytes and acts on muscle cells to inhibit muscle growth. [7]
The MSTN gene provides instructions for making a protein called myostatin, which is active in muscles used for movement (skeletal muscles) both before and after birth. A 2010 research paper in the Journal of Musculoskeletal & Neuronal Interactions, which was discussed outside of academic circles, [ 3 ] linked Myostatin to muscle mass and bone ...
Another form of myostatin inhibition is gene therapy. [ 10 ] Another monoclonal antibody, bimagrumab , works as an antagonist of the ACVR2 and ACVR2B receptors, preventing myostatin and activin A from binding. [ 11 ]
Pseudoathletic appearance is a medical sign meaning to have the false appearance of a well-trained athlete due to pathologic causes (disease or injury) instead of true athleticism.
The MSTN gene also plays a big role in muscle development. It provides instructions for making a protein called myostatin . This protein transforming growth factor beta (TGFβ) superfamily, which is a group of proteins that help control the growth and development of tissues throughout the body.
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Dr Emmeline Hill is an Irish horse geneticist who is credited with discovering a gene for speed in horses.. Dr Hill has published a paper in the peer-reviewed scientific journal PLoS ONE entitled "A sequence polymorphism in MSTN predicts sprinting ability and racing stamina in Thoroughbred horses", which describes the identification of the DNA sequence variant in the horse myostatin gene.
Many proteins have since been described as members of the TGF-β superfamily in a variety of species, including invertebrates as well as vertebrates and categorized into 23 distinct gene types that fall into four major subfamilies: [3] [4] [5] The TGF-β subfamily; The bone morphogenetic proteins and the growth differentiation factors