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Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use. Increasing its dosage may re-amplify the drug's effects; however, this may accelerate tolerance, further reducing the drug's effects.
Tolerability, however, is often relative to the severity of the medical condition a drug is designed to treat. [1] For instance, cancer patients may tolerate significant pain or discomfort during a chemotherapeutic study with the hope of prolonging survival or finding a cure, whereas patients experiencing a benign condition, such as a headache ...
Cross-tolerance is a phenomenon that occurs when tolerance to the effects of a certain drug produces tolerance to another drug. It often happens between two drugs with similar functions or effects—for example, acting on the same cell receptor or affecting the transmission of certain neurotransmitters .
A higher weight indicates a larger difference between the most harmful drug on the criterion and no harm. This chart is supported by the data taken from the study "Drug harms in the UK: a multi-criteria decision analysis", by David Nutt, Leslie King and Lawrence Phillips, on behalf of the Independent Scientific Committee on Drugs.
English: A rational scale to assess the harm of drugs. Data source is the March 24, 2007 article: Nutt, David, Leslie A King, William Saulsbury, Colin Blakemore. "Development of a rational scale to assess the harm of drugs of potential misuse" The Lancet 2007; 369:1047-1053.
Psychosis risk increases 81% on high-dose amphetamine. For this study, researchers analyzed medical data from adults between the ages of 16 and 35 treated at Mass General Brigham between 2005 and ...
Drug intolerance or drug sensitivity refers to an inability to tolerate the adverse effects of a medication, generally at therapeutic or subtherapeutic doses. Conversely, a patient is said to be "tolerating" a drug when they can tolerate its adverse effects.
Siegel suggested that compensatory CRs allow the organism to maintain a normal physiological state despite the administration of a drug and that they help to explain tolerance to drugs. The conditioned compensatory response may take place only in the case of subconscious learning, as the effects of conscious expectancies may tend to be in the ...