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Sodium thiosulfate (sodium thiosulphate) is an inorganic compound with the formula Na 2 S 2 O 3 ·(H 2 O) x. Typically it is available as the white or colorless pentahydrate (x = 5), which is a white solid that dissolves well in water.
Sodium thiosulfate is a classical antidote to cyanide poisoning, [10] For this purpose it is used after the medication sodium nitrite and typically only recommended for severe cases. [4] [6] It is given by injection into a vein. [4] In this use, sodium nitrite creates methemoglobinemia which removes cyanide from mitochondria. [6]
It is used by major non-governmental organizations such as UNICEF [24] to treat water in emergencies. Sodium dichloroisocyanurate tablets are available in a range of concentrations to treat differing volumes of water [25] to give the World Health Organization's recommended 5ppm [26] available chlorine. They are effervescent tablets allowing the ...
Thiosulfate: The evidence for sodium thiosulfate's use is based on animal studies and case reports: the small quantities of cyanide present in dietary sources and in cigarette smoke are normally metabolized to relatively harmless thiocyanate by the mitochondrial enzyme rhodanese (thiosulfate cyanide sulfurtransferase), which uses thiosulfate as ...
Sodium nitrite/sodium thiosulfate, sold under the brand name Nithiodote, is a fixed-dose combination medication used as an antidote for cyanide poisoning. [1] It contains sodium thiosulfate and sodium nitrite. [1] It is given by intravenous infusion into a vein. [1] It was approved for medical use in the United States in January 2011. [2]
Thiosulfate (IUPAC-recommended spelling; sometimes thiosulphate in British English) is an oxyanion of sulfur with the chemical formula S 2 O 2− 3.Thiosulfate also refers to the compounds containing this anion, which are the salts of thiosulfuric acid, such as sodium thiosulfate Na 2 S 2 O 3 and ammonium thiosulfate (NH 4) 2 S 2 O 3.
The salt is typically prepared by reduction of gold(III) chloride with thiosulfate: [3] 4 Na 2 S 2 O 3 + AuCl 3 → Na 3 [Au(S 2 O 3) 2] + Na 2 S 4 O 6 + 3 NaCl. The compound was first synthesized in 1845 by Mathurin-Joseph Fordos and A. Gélis who were researching chemicals used in the Daguerrotype photographic process.
This absorption will cause the solution to change its colour from deep blue to light yellow when titrated with standardized thiosulfate solution. This indicates the end point of the titration. Iodometry is commonly used to analyze the concentration of oxidizing agents in water samples, such as oxygen saturation in ecological studies or active ...