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Memantine is a low-affinity voltage-dependent uncompetitive antagonist at glutamatergic NMDA receptors. [32] [33] By binding to the NMDA receptor with a higher affinity than Mg 2+ ions, memantine is able to inhibit the prolonged influx of Ca 2+ ions, particularly from extrasynaptic receptors, which forms the basis of neuronal excitotoxicity.
Common symptoms of viral meningitis include fever, headache, neck stiffness, nausea, vomiting, sensitivity to light and confusion, says Nagata. "In severe cases, it may cause seizures, coma or a ...
Memantine (Namenda) - treats Dementia and Alzheimer's. N. Neurontin – an anticonvulsant which is sometimes used as a mood stabilizer, anti-anxiety agent or to ...
Memantine/donepezil, sold under the brand name Namzaric among others, is a fixed dose combination medication used for the treatment of dementia of the Alzheimer's type. [1] It contains memantine , as the hydrochloride, a NMDA receptor antagonist ; and donepezil as the hydrochloride, an acetylcholinesterase inhibitor . [ 1 ]
NMDA receptor antagonists induce a state called dissociative anesthesia, marked by catalepsy, amnesia, and analgesia. [1] Ketamine is a favored anesthetic for emergency patients with unknown medical history and in the treatment of burn victims because it depresses breathing and circulation less than other anesthetics.
A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
Olney's lesions, also known as NMDA receptor antagonist neurotoxicity (NAT), is a form of brain damage consisting of selective death of neurons but not glia, observed in restricted brain regions of rats and certain other animal models exposed to large quantities of psychoactive drugs that inhibit the normal operation of the neuronal NMDA receptor.
Most neurons have the ability to use other fuels besides glucose (e.g. lactic acid, ketones).Knowledge of the "switchover" process is incomplete. [further explanation needed] The most severe neuroglycopenic symptoms occur with hypoglycemia caused by excess insulin because insulin reduces the availability of other fuels by suppressing ketogenesis and gluconeogenesis.