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When synthesized and absorbed in the intestines, urolithin A enters the systemic circulation where it becomes available to tissues throughout the body where it is further subjected to additional chemical transformations (including glucuronidation, methylation, sulfation, or a combination of them) within the enterocytes and hepatocytes. [9]
Urolithins are microflora metabolites of dietary ellagic acid derivatives, such as ellagitannins. [1] They are produced in the gut , and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing foods, such as pomegranate . [ 2 ]
Functional weakness is weakness of an arm or leg without evidence of damage or a disease of the nervous system. Patients with functional weakness experience symptoms of limb weakness which can be disabling and frightening such as problems walking or a 'heaviness' down one side, dropping things or a feeling that a limb just doesn't feel normal or 'part of them'.
Single symptoms may be assigned a diagnostic label, such as "functional chest pain", "functional constipation" or "functional seizures". Characteristic collections of symptoms might be described as one of the functional somatic syndromes. [2] A syndrome is a collection of symptoms. Somatic means 'of the body'.
For women, it has been found that treatment can improve sexual function, thus helping restore sexual desire. [23] Depression and libido decline often coincide, with reduced sex drive being one of the symptoms of depression. [24] Those with depression often report the decline in libido to be far reaching and more noticeable than other symptoms. [24]
Classified as a "conversion disorder" by the DSM-IV, a psychogenic disease is a condition in which mental stressors cause physical symptoms matching other disorders. The manifestation of physical symptoms without biologically identifiable cause results from disruptions in normal brain function due to psychological stress.
The sensory function of substance P is thought to be related to the transmission of pain information into the central nervous system. Substance P coexists with the excitatory neurotransmitter glutamate in primary afferents that respond to painful stimulation. [ 30 ]
Conversion disorder involves the unintentional production of symptoms or deficits affecting motor or sensory function that are not fully explained by a neurological or medical condition. [1] This can manifest as paralysis, for example. It generally involves psychological factors, and symptoms may worsen in the context of situational conflict. [1]