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Despite having a similar therapeutic mechanism of action as first-line medications containing amphetamine, the prescription of dextromethamphetamine for ADHD is rare due its relatively greater reinforcing potential, in addition to the comparable efficacy and presumably greater safety of methylphenidate and amphetamine.
Methylphenidate's mechanism of action in the release of dopamine and norepinephrine is fundamentally different from most other phenethylamine derivatives, as methylphenidate is thought to increase neuronal firing rate, [129] [130] [131] whereas amphetamine reduces firing rate, but causes monoamine release by reversing the flow of the monoamines ...
Adderall is made from amphetamine mixed salts and Concerta is made from methylphenidate. There are other trade name medications like Strattera, made from atomoxetine, and Qelbree, made from ...
Amphetamine is a potent central nervous system (CNS) stimulant of the phenethylamine class that is approved for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. [82] Amphetamine is also used off-label as a performance and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant.
Amphetamines and methylphenidate are classified by the Drug Enforcement Administration as Schedule II controlled substances, the same designation given to cocaine, OxyContin and fentanyl.
One in four U.S. adults suspects they may have ADHD and drugs are a first line of treatment for this condition. But what does research say about their impact on the brain and quality of life?
Methylphenidate, one of the most widely used NDRIs.. A norepinephrine–dopamine reuptake inhibitor (NDRI) is a type of drug that inhibits the reuptake of the monoamine neurotransmitters norepinephrine and dopamine and thereby increases extracellular levels of these neurotransmitters and noradrenergic and dopaminergic neurotransmission. [1]
Ritalin (methylphenidate) – a stimulant used to treat ADHD; ReVia – an opioid antagonist primarily used in the management of alcohol dependence, opioid dependence or other impulse control/addictive behaviors such as habitual self-mutilation; Rexulti (brexpiprazole) – atypical antipsychotic used to treat mood and psychotic disorders
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