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In 1983, he founded CNS Productions, a publishing and distribution company specializing in topics related to addiction, neuropharmacology, and brain chemistry. He is the publisher of Uppers, Downers, All Arounders , a textbook on the neurochemistry and neuropharmacology of psychoactive drugs .
One form of behavioral neuropharmacology focuses on the study of drug dependence and how drug addiction affects the human mind. Most research has shown that the major part of the brain that reinforces addiction through neurochemical reward is the nucleus accumbens. The image to the right shows how dopamine is projected into this area.
Darryl S. Inaba (born June 16, 1946) is an American pharmacist who is the remaining owner and President of CNS Productions, Inc. in Medford, OR. He is an associate professor of Pharmacology at the UCSF Medical Center in San Francisco, California, and the Director of Clinical and Behavioral Health Services at ARC (Addiction Recovery Center) in Medford, Oregon.
George F. Koob (born 1947) is a Professor and former Chair of the Committee on the Neurobiology of Addictive Disorders at the Scripps Research Institute [1] and Adjunct Professor of Psychology, Psychiatry, and Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California, San Diego.
CNS Productions is a publisher of educational materials — primarily textbooks and instructional DVDs — dealing with psychoactive drugs and addiction.It was formed in 1983 by Paul Steinbroner, with long-time collaborator William E. Cohen who had an extensive background in medical film production.
With abstinence from alcohol and cross-tolerant drugs these changes in neurochemistry may gradually return towards normal. [ 22 ] [ 23 ] Adaptations to the NMDA system also occur as a result of repeated alcohol intoxication and are involved in the hyper-excitability of the central nervous system during the alcohol withdrawal syndrome.
ΔFosB is the most significant gene transcription factor in addiction since its viral or genetic overexpression in the nucleus accumbens is necessary and sufficient for many of the neural adaptations and behavioral effects (e.g., expression-dependent increases in self-administration and reward sensitization) seen in drug addiction.
For drug addiction, the synapse is the most likely target as it involves communication between neurons. Lack of sensory communication in neurons is often an outward sign of drug abuse , and so neuroproteomics is being applied to find out what proteins are being affected to prevent the transport of neurotransmitters.