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Theophylline's first clinical use came in 1902 as a diuretic. [35] It took an additional 20 years until it was first reported as an asthma treatment. [ 36 ] The drug was prescribed in a syrup up to the 1970s as Theostat 20 and Theostat 80, and by the early 1980s in a tablet form called Quibron.
[9] [7] [10] A ratio of 5:1 theophylline to ephedrine is usually used in combinations of the drugs. [11] Later research found that the combination was no more effective for asthma than theophylline alone but produced more side effects. [9] [1] [12] [7]
[3] [4] [5] However, at high dose, it may lead to cardiac arrhythmias, hypertension, seizures or other serious cardiovascular and/or central nervous system adverse effects. [ 6 ] [ 7 ] [ 8 ] Tedral is contraindicated in individuals with hypersensitivity to theophylline, ephedrine and/or phenobarbital.
Over 45 for men and over 55 for women. Family history. Having a family history of early heart disease. Sex. People born male are at increased risk. Congenital defects. Having problems with your ...
This suggests that its antiasthmatic effects are mediated by another mechanism, perhaps its actions on phosphodiesterase. [1] From a pharmacokinetic point of view, doxofylline importantly differs from theophylline also because it lacks the ability to interfere with the cytochrome enzymes CYP1A2 , CYP2E1 and CYP3A4 , thus preventing significant ...
ESPN talk show "Around the Horn" will go off the air next summer, ending a more than two-decade run on weekday afternoons. The Athletic and the New York Post previously reported that the ...
It was a combination of theophylline, ephedra, [1] and hydroxyzine, and taken by mouth. [ 2 ] [ 3 ] It is no longer manufactured in the US due to approval of ephedra being withdrawn by the FDA . [ citation needed ]
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