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Valproate is a medication primarily used to treat epilepsy and bipolar disorder, also effective in preventing migraine headaches.
To carry out gene expression, a cell must control the coiling and uncoiling of DNA around histones.This is accomplished with the assistance of histone acetyl transferases (HAT), which acetylate the lysine residues in core histones leading to a less compact and more transcriptionally active euchromatin, and, on the converse, the actions of histone deacetylases (HDAC), which remove the acetyl ...
Since 1983, Depakote ER has been a good source of revenue for drug manufacturers. The drug is mainly used in the treatment of bipolar disorder, migraines, and seizures. The brand and its generic ...
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Depakote (valproic acid/sodium valproate) – an antiepileptic and mood stabilizer used to treat bipolar disorder, neuropathic pain and others; sometimes called an antimanic medication. Depakene is the trade name for the same drug prepared without sodium. Desyrel – an atypical antidepressant used to treat depression and insomnia
Depakote 10 March 1983 [56] eslicarbazepine: Aptiom 11 August 2013 [57] [58] ethosuximide: Zarontin 2 November 1960 [59] 1955 [46] 1962 [51] ethotoin: Peganone 22 April 1957 [60] everolimus: Afinitor/Votubia 30 January 2009 [61] felbamate: Felbatol 29 July 1993 [62] fosphenytoin: Cerebyx 5 August 1996 [63]
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Minor limb malformations seen after valproate exposure. Fetal valproate spectrum disorder (FVSD), previously known as fetal valproate syndrome (FVS), is a rare disease caused by prenatal exposure to valproic acid (VPA), a medication commonly used to treat epilepsy, bipolar disorder, and migraines.