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The globus pallidus receives input from the striatum and sends inhibitory output to a number of motor-related areas. The substantia nigra is the source of the striatal input of the neurotransmitter dopamine, which plays an important role in basal ganglia function. The subthalamic nucleus mainly receives input from the striatum and cerebral ...
The striatum includes the caudate nucleus (top), and the lentiform nucleus (the putamen (right) and the globus pallidus (lower left)) The striatum is the largest structure of the basal ganglia. The striatum is divided into two subdivisions, a ventral striatum and a dorsal striatum, based upon function and connections.
It is part of the basal ganglia, which, among many other functions, regulate movements that occur on the subconscious level. The globus pallidus has a predominantly inhibitory effect on movement regulation, balancing cerebellar excitation. Pulsatile and regular interaction between these complementary systems allows smooth and controlled movement.
As the GPi is one of the direct output centers of the basal ganglia, this causes disinhibition of the thalamus, increasing overall ease of initiating and maintaining movement. As this pathway only contains one synapse (from the striatum to the internal globus pallidus), it is known as the direct pathway .
The function of the STN is not fully understood but it is believed that, as a component of the basal ganglia, it plays a part in the so-called "hyperdirect" and "indirect" pathways of motor control, as opposed to the direct pathway which bypasses the STN on its way from the Striatum to the internal pallidum.
The caudate nucleus is one of the structures that make up the corpus striatum, which is part of the basal ganglia in the human brain. [1] Although the caudate nucleus has long been associated with motor processes because of its role in Parkinson's disease, [2] [clarification needed] [3] it also plays important roles in nonmotor functions, such as procedural learning, [4] associative learning ...
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The basal ganglia are located bilaterally, and have rostral and caudal divisions. The putamen is located in the rostral division as part of the striatum. The basal ganglia receive input from the cerebral cortex, via the striatum. This is a transverse section of the striatum from a structural MR image.