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Splenomegaly is an enlargement of the spleen. [1] The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen.Splenomegaly is one of the four cardinal signs of hypersplenism which include: some reduction in number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination; a compensatory proliferative response in the bone marrow; and the ...
Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly).Hepatosplenomegaly can occur as the result of acute viral hepatitis, infectious mononucleosis, and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage disease.
If an individual's spleen is enlarged, as is frequent in mononucleosis, most physicians will advise against activities (such as contact sports) where injury to the abdomen could be catastrophic. [10] Patients whose spleens have been removed via a splenectomy must receive immunizations to help prevent infections such as pneumonia. This helps to ...
The spleen is massively enlarged. It shows dilated sinusoids lined with reticulum cells. There is a marked erythrophagocytosis and lymphocytic infiltration of the pulp. Peripheral smear for malarial parasite is usually negative. Condition may show features of hypersplenism in severe form like anemia and thrombocytopenia.
Splenic infarction is a condition in which blood flow supply to the spleen is compromised, [1] leading to partial or complete infarction (tissue death due to oxygen shortage) in the organ. [2] Splenic infarction occurs when the splenic artery or one of its branches are occluded, for example by a blood clot. [3]
Splenomegaly can result in hematologic disturbances and abdominal pain and can increase the risk for splenic rupture, which also causes spleen pain, from blunt trauma, resulting in life-threatening internal bleeding. [2] Many conditions can cause splenomegaly, such as various infections, liver disease, and cancer. [2]
A Florida doctor who is accused of removing an Alabama man’s liver instead of the spleen, resulting in “immediate and catastrophic death,” had his medical license suspended.. In an emergency ...
The spleen is enlarged in a variety of conditions such as malaria, mononucleosis and most commonly in cancers of the lymphatics, such as lymphomas or leukemia. It is removed under the following circumstances: When it becomes very large such that it becomes destructive to platelets/red blood cells or rupture is imminent; For diagnosing certain ...