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Neuroblastoma often spreads to other parts of the body before any symptoms are apparent, and 50 to 60% of all neuroblastoma cases present with metastases. [8] The most common location for neuroblastoma to originate (i.e., the primary tumor) is in the adrenal glands. This occurs in 40% of localized tumors and in 60% of cases of widespread disease.
Adrenal neuroblastoma typically presents with a rapidly enlarging abdominal mass. Although the tumor has often spread to distant parts of the body at the time of diagnosis, this cancer is unusual in that many cases are highly curable when the spread is limited to the liver, skin, and/or bone marrow (stage IVS).
This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. [5] N-Myc is highly expressed in the fetal brain and is critical for normal brain development. [6] The MYCN gene has an antisense RNA, N-cym or MYCNOS, transcribed from the opposite strand which can be translated to form a protein ...
Retinoblastoma is a rare form of eye neoplasm (found in the retina) that is mostly found in children, being the most common intraocular malignancy of infancy and childhood. The incidence is of one case per every 15,000 to 20,000 live births, and some of the most common symptoms of this disease are leukocoria and strabismus, iris rubeosis ...
Pleomorphic anaplastic neuroblastoma (PAN) is a striking aspect of neuroblastoma first described by Cozzutto and Carbone in 1988. Another case was thereafter reported by Cowan, et al. with cytogenetic and immunohistological analysis in a 28-year-old man.
In early medicine and anatomy, the location of the soul was hypothesized to be located within the body. Aristotle and Plato understood the soul as an incorporeal form but closely related to the physical world. The Hippocratic Corpus chronicles the evolution of thought that the soul is located within the body and is manifested in diseased ...
The axon hillock is a specialized domain of the neuronal cell body from which the axon originates. A high amount of protein synthesis occurs in this region, as it contains many Nissl granules (which are ribosomes wrapped in RER) and polyribosomes. Within the axon hillock, materials are sorted as either items that will enter the axon (like the ...
Winged hippocamp in an Art Deco fountain, Kansas City, Missouri, (1937). The hippocampus or hippocamp, also hippokampos (plural: hippocampi or hippocamps; Ancient Greek: ἱππόκαμπος, from ἵππος, 'horse', and κάμπος, 'sea monster' [1]), often called a sea-horse [2] in English, [citation needed] is a mythological creature shared by Phoenician, [3] Etruscan, Pictish, Roman ...