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Compared with other existing imaging technologies, laser speckle contrast imaging has several obvious advantages. It can uses simple and cost-effective instrument to return excellent spatial and temporal resolution imaging. And due to these strengths, laser speckle contrast imaging has been involved in mapping blood flow for decades.
Laser Doppler imaging (LDI) is an imaging method that uses a laser beam to image live tissue. When the laser light reaches the tissue, the moving blood cells generate Doppler components in the reflected (backscattered) light. The light that comes back is detected using a photodiode that converts it into an electrical signal.
Therefore, there is an urgent need for a way to measure blood flow. However, blood flow is difficult to measure because of sensitivity and stability of the measurement as it depends on magnitude of flow, location, and the diameter of individual vessels. [2] Current imaging modalities used to measure blood flow include Doppler ultrasound, PET ...
Initial efforts to measure blood flow using OCT utilized the Doppler effect. [41] [42] By comparing the phase of successive A-mode scans, the velocity of blood flow can be determined via the Doppler equation. This was deemed Optical Doppler Tomography; the development of spectral domain OCT (SD-OCT) and swept-source OCT (SS-OCT) greatly ...
The photoacoustic Doppler effect is a type of Doppler effect that occurs when an intensity modulated light wave induces a photoacoustic wave on moving particles with a specific frequency. The observed frequency shift is a good indicator of the velocity of the illuminated moving particles. A potential biomedical application is measuring blood flow.
SV-OCT uses the inter-frame variance of image intensities to compute blood flow. Areas that have high flow will have higher motion of scattering particles and this information is encoded in the speckle pattern. [citation needed] SV-OCT has advantages for microvasculature imaging due to its high sensitivity and independence to the Doppler angle.
Doppler Optical Coherence Tomography is an extension of OCT, where it combines the Doppler effect principle to achieve high resolution tomographic images in biological tissues. And because of its high resolution and velocity sensitivity, there are many applications in the medical field. The basic phenomenon of Doppler OCT can be explained below.
Laser Doppler velocimetry, also known as laser Doppler anemometry, is the technique of using the Doppler shift in a laser beam to measure the velocity in transparent or semi-transparent fluid flows or the linear or vibratory motion of opaque, reflecting surfaces. The measurement with laser Doppler anemometry is absolute and linear with velocity ...
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