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[1] Anti-dsDNA antibodies are highly associated with glomerulonephritis in SLE, although some patients with high titers of anti-dsDNA antibodies do not develop renal disease. This is most likely due to the fact that anti-dsDNA are a heterogeneous population, some of which have been found not to be pathogenic.
After incubation with serum containing anti-dsDNA antibodies and fluorescent-labelled anti-human antibodies, the kinetoplast will fluoresce. The lack of other nuclear antigens in this organelle means that using C. luciliae as a substrate allows for the specific detection of anti-dsDNA antibodies.
ANA screening yields positive results in many connective tissue disorders and other autoimmune diseases, and may occur in normal individuals. Subtypes of antinuclear antibodies include anti-Smith and anti-double stranded DNA antibodies (which are linked to SLE) and anti-histone antibodies (which are linked to drug-induced lupus). Anti-dsDNA ...
A value of greater than 1.5 units relative to a control serum is considered a positive ELISA test for the anti-histone antibodies. Patients with drug-induced lupus erythematosus typically have positive tests for anti-histone antibodies but do not have indications for anti-dsDNA antibodies. Patients with idiopathic systemic lupus erythematosus ...
Crithidia luciliae is a flagellate parasite that uses the housefly, Musca domestica, as a host. [1] [2] As part of the family of Trypanosomatidae, it is characterised by the presence of a kinetoplast, a complex network of interlocking circular double-stranded DNA (dsDNA) molecules.
August 1, 2024 at 11:17 PM The Washington Post - Getty Images House Freedom Caucus Chairman Bob Good, R-Va., has lost his primary recount, a Virginia court certified Thursday, cementing his narrow ...
This 10-minute ab workout is brutal — but I saw results in just 1 week. Danielle Page. March 23, 2022 at 11:42 AM. ... How much does the Daisy Keech ab workout cost?
President Donald Trump has nominated Pierre M. Gentin, chief legal officer of consulting firm McKinsey & Co, to serve as general counsel at the U.S. Commerce Department, according to U.S. Senate ...