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Filgrastim is a recombinant form of the naturally occurring granulocyte colony-stimulating factor (G-CSF). [21] It works by stimulating the body to increase neutrophil production. [21] Filgrastim was approved for medical use in the United States in 1991. [21] It is on the World Health Organization's List of Essential Medicines.
The recombinant human G-CSF (rhG-CSF) synthesised in an E. coli expression system is called filgrastim. The structure of filgrastim differs slightly from the structure of the natural glycoprotein. Most published studies have used filgrastim. [citation needed] Filgrastim was first marketed by Amgen with the brand name Neupogen. Several bio ...
12981 Ensembl ENSG00000164400 ENSMUSG00000018916 UniProt P04141 P01587 RefSeq (mRNA) NM_000758 NM_009969 RefSeq (protein) NP_000749 NP_034099 Location (UCSC) Chr 5: 132.07 – 132.08 Mb Chr 11: 54.14 – 54.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein family Granulocyte-macrophage colony-stimulating factor three-dimensional structure of recombinant human granulocyte ...
Severe congenital neutropenia (SCN), also often known as Kostmann syndrome or disease, is a group of rare disorders that affect myelopoiesis, causing a congenital form of neutropenia, usually without other physical malformations.
Pegfilgrastim, sold under the brand name Neulasta among others, is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (GCSF) analog filgrastim. [19] It serves to stimulate the production of white blood cells (neutrophils). [19] [21] Pegfilgrastim was developed by Amgen. [22]
Bonner played 10 seasons in Phoenix after the Mercury selected her with the No. 5 overall pick in the 2009 WNBA draft before she was traded to the Sun in 2020. The USA TODAY app gets you to the ...
Filgrastim is typically dosed in the 10 microgram/kg level for 4–5 days during the harvesting of stem cells. The documented adverse effects of filgrastim include splenic rupture , acute respiratory distress syndrome , alveolar hemorrhage, and allergic reactions (usually experienced in first 30 minutes).
A new pain relief drug, suzetrigine, is a prescription pill that’s taken every 12 hours after a larger starter dose. It will be sold under the brand name Journavx.