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  2. DNA repair - Wikipedia

    en.wikipedia.org/wiki/DNA_repair

    This then allows recruitment of the DNA repair enzyme MRE11, to initiate DNA repair, within 13 seconds. [51] γH2AX, the phosphorylated form of H2AX is also involved in the early steps leading to chromatin decondensation after DNA double-strand breaks. The histone variant H2AX constitutes about 10% of the H2A histones in human chromatin.

  3. The best muscle pain relief creams of 2025, according to ...

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    Cost: $7 | Active ingredients: Lidocaine | Type: Cream | Amount: 4.3 ounces. Lidocaine is another popular ingredient found in pain relief creams. It's a topical anesthetic that's often used to ...

  4. Oxoguanine glycosylase - Wikipedia

    en.wikipedia.org/wiki/Oxoguanine_glycosylase

    OGG1 is the primary enzyme responsible for the excision of 8-oxoguanine (8-oxoG), a mutagenic base byproduct that occurs as a result of exposure to reactive oxygen species (ROS). OGG1 is a bifunctional glycosylase, as it is able to both cleave the glycosidic bond of the mutagenic lesion and cause a strand break in the DNA backbone.

  5. DNA glycosylase - Wikipedia

    en.wikipedia.org/wiki/DNA_glycosylase

    DNA glycosylases are a family of enzymes involved in base excision repair, classified under EC number EC 3.2.2. Base excision repair is the mechanism by which damaged bases in DNA are removed and replaced.

  6. DNA repair-deficiency disorder - Wikipedia

    en.wikipedia.org/wiki/DNA_repair-deficiency_disorder

    Individuals with an inherited impairment in DNA repair capability are often at increased risk of cancer. [45] When a mutation is present in a DNA repair gene, the repair gene will either not be expressed or be expressed in an altered form. Then the repair function will likely be deficient, and, as a consequence, damages will tend to accumulate.

  7. Nucleotide excision repair - Wikipedia

    en.wikipedia.org/wiki/Nucleotide_excision_repair

    Nucleotide excision repair is a DNA repair mechanism. [2] DNA damage occurs constantly because of chemicals (e.g. intercalating agents ), radiation and other mutagens . Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR).

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    Two of L'Oreal's powerhouse Revitalift moisturizers — both the day and the night formulas — are on sale for under $15. These firming, anti-wrinkle creams do the work of several individual ...

  9. Enzyme replacement therapy - Wikipedia

    en.wikipedia.org/wiki/Enzyme_replacement_therapy

    This procedure is expensive; in the United States, it may cost over $200,000 annually. [10] The distribution of the therapeutic enzyme in the body (biodistribution) after these IV infusions is not uniform. [10] The enzyme in less available to certain areas in the body, like the bones, lungs, brain.

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