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Heparin is an anticoagulant, and if used as a catheter lock solution it could leak into the blood circulation of the patient. Therefore it has been associated with catheter-related bleeding and heparin induced thrombocytopenia (HIT). [8] [9] Citrate catheter lock solutions are being used in three different concentrations – 4%, 30% and 46.7%.
Randomized controlled trial [5]. Blind trial [6]; Non-blind trial [7]; Adaptive clinical trial [8]. Platform Trials; Nonrandomized trial (quasi-experiment) [9]. Interrupted time series design [10] (measures on a sample or a series of samples from the same population are obtained several times before and after a manipulated event or a naturally occurring event) - considered a type of quasi ...
The “Cardioneuroablation” is a technique created in the nineties and patented in USA, aiming to eliminate the cardiac branch of vagal reflex in order to treat the neurocardiogenic syncope without pacemaker implantation. [6] [7] It is performed without surgery, by using radiofrequency catheter ablation with one-day hospital. [citation needed]
Uterine balloon tamponade (UBT) is a non-surgical method of treating refractory postpartum hemorrhage.Once postpartum hemorrhage has been identified and medical management given (including agents such as uterotonics and tranexamic acid), UBT may be employed to tamponade uterine bleeding without the need to pursue operative intervention.
This contrasts with a double-blinded trial, where information is withheld both from the researchers and the participants to reduce bias. [ 2 ] [ 3 ] Open-label trials may be appropriate for comparing two similar treatments to determine which is most effective, such as a comparison of different prescription anticoagulants , [ 4 ] or possible ...
Industry-sponsored Phase 3 trial of cangrelor versus placebo in 11,000 patients undergoing percutaneous coronary intervention. THEMIS, AstraZeneca, Co-Chair and Co-PI [ 19 ] This is an international, multicenter, randomized trial of patients with diabetes and stable coronary artery disease randomized to the oral antiplatelet ticagrelor or to ...
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The devices are implanted without open heart surgery. The valve delivery system is inserted in the body, the valve is positioned and then implanted inside the diseased aortic valve, and then the delivery system is removed. The catheter-based delivery system can be inserted into the body from one of several sites. [14]