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Although natural TBP has been identified in ocean sediments as a metabolite of marine fauna, [5] the commercial product is prepared industrially. In 2001, the production volume of TBP was estimated to be 2500 tonnes/year in Japan and 9500 tonnes/year worldwide. [2] TBP can be prepared by the controlled reaction of elemental bromine with phenol: [3]
Tributyl phosphate, known commonly as TBP, is an organophosphorus compound with the chemical formula (CH 3 CH 2 CH 2 CH 2 O) 3 PO. This colourless, odorless liquid finds some applications as an extractant and a plasticizer .
2,4,6-Tri-tert-butylphenol (2,4,6-TTBP) is a phenol symmetrically substituted with three tert-butyl groups and thus strongly sterically hindered. 2,4,6-TTBP is a readily oxidizable aromatic compound and a weak acid. It oxidizes to give the deep-blue 2,4,6-tri-tert-butylphenoxy radical.
OSHA records show it as an irritant and has developed suggested test methods for its detection. [7] A European Union risk assessment report into the molecule dated May 2006 suggested it had potential depigmenting properties and was a potential endocrine disruptor.
Triphenyl phosphate has been detected in the environment. [9] Other triaryl phosphates have been known to enter aquatic environments through volatilization and leaching from plastics, through hydraulic fluid leakages, and, to a lesser degree, through manufacturing processes. [5]
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Phenol is also a versatile precursor to a large collection of drugs, most notably aspirin but also many herbicides and pharmaceutical drugs. Phenol is a component in liquid–liquid phenol–chloroform extraction technique used in molecular biology for obtaining nucleic acids from tissues or cell culture samples.
President Donald Trump has nominated Pierre M. Gentin, chief legal officer of consulting firm McKinsey & Co, to serve as general counsel at the U.S. Commerce Department, according to U.S. Senate ...