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The anti-TNF-α monoclonal antibody infliximab is a major biological therapy for inflammatory bowel disease. Biological therapy, the use of medications called biopharmaceuticals or biologics that are tailored to specifically target an immune or genetic mediator of disease, plays a major role in the treatment of inflammatory bowel disease. [1]
Before using biologics to treat psoriasis, treatment with topical moisturizers or steroids, or light therapy may provide relief. Other drugs which may provide relief include acitretin , ciclosporin , and methotrexate , but since these drugs have their own major side effects, doctors and patients should discuss whether to try one of these or a ...
multiple sclerosis, Crohn's disease Navicixizumab [41] mab: chimeric/ humanized: DLL4 and VEGFA: cancer Navivumab [12] mab: human: Hemagglutinin (influenza) Naxitamab: Danyelza: humanized: c-Met: Y: high-risk neuroblastoma and refractory osteomedullary disease Nebacumab: mab: human: endotoxin: sepsis Necitumumab [100] Portrazza: mab: human ...
Infliximab is also prescribed (out of indication) for the treatment of Behçet's disease. [35] Infliximab is the most frequently used biological agent in treating relapsing polychondritis. [36] Half of the patients saw benefit from this treatment, and a few other patients experienced infections that in some cases lead to death. [36] [37]
The World Association of Sarcoidosis and other Granulomatous Disorders, also known as WASOG is an organisation of physicians involved in the diagnosis and treatment of sarcoidosis and related conditions.
Sarcoidosis may resolve without any treatment within a few years. [2] [5] However, some people may have long-term or severe disease. [5] Some symptoms may be improved with the use of anti-inflammatory drugs such as ibuprofen. [8] In cases where the condition causes significant health problems, steroids such as prednisone are indicated. [9]
A combination of azathioprine and infliximab treatment may be more effective than a single dose of infliximab to induce steroid-free remission for people with active Crohn's disease. [9] Azathioprine treatment may lead to rare but life-threatening side effects. The rare side effects include leukopenia or pancreatitis. [9]
Colchicine or low-dose prednisone may also be used. Treatment with NSAIDs or corticosteroids leads to symptomatic relief of Löfgren syndrome 90% of the time within six weeks of symptom onset. Rarely, long-term joint damage (chronic sarcoid arthropathy) may develop. Disease modifying antirheumatic drugs, also known as DMARDs, are used for such ...