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The pacemaker current (I f, or I Kf, also called funny current) is an electric current in the heart that flows through the HCN channel or pacemaker channel. Such channels are important parts of the electrical conduction system of the heart and form a component of the natural pacemaker .
Hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) are located mainly in pacemaker cells, these channels become active at very negative membrane potentials and allow for the passage of both Na + and K + into the cell (which is a movement known as a funny current, I f). These poorly selective, cation (positively charged ...
HCN4 is the main isoform expressed in the sinoatrial node, but low levels of HCN1 and HCN2 have also been reported.The current through HCN channels, called the pacemaker current (I f), plays a key role in the generation and modulation of cardiac rhythmicity, [13] as they are responsible for the spontaneous depolarization in pacemaker action potentials in the heart.
Evidence in support of the active presence of K +, Ca 2+, Na + channels and Na + /K + exchanger during the pacemaker phase have been variously reported in the literature, but several indications point to the “funny”(I f) current as one of the most important. [5] (see funny current).
Pacemakers are also sometimes used to regulate the heartbeats in people with congenital heart disease, a group of conditions that affect about 1% of people born in the U.S., according to the ...
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I love exploring the shapes, emotions, and relationships between humans and animals through my illustrations. I also enjoy crafting their stories through drawing; whether they’re real or ...