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Produces antibody molecules [14] [4] Plasma cell: Lymphocyte: B cell: Plasma B cells; Effector B cells; Plasmocytus; 8-10 Active B cells that produces large amounts of antibodies [4] [15] Memory B cell: Lymphocyte: B cell: MBC; 8-10 Memorizes the characteristics of the antigens; Triggers an accelerated and robust secondary immune response [4 ...
These antibodies are transported from the plasma cells by the blood plasma and the lymphatic system to the site of the target antigen (foreign substance), where they initiate its neutralization or destruction. B cells differentiate into plasma cells that produce antibody molecules closely modeled after the receptors of the precursor B cell. [3]
Long-lived plasma cells (LLPCs) are a distinct subset of plasma cells that play a crucial role in maintaining humoral memory and long-term immunity. [1] They continuously produce and secrete high-affinity antibodies into the bloodstream, conversely to memory B cells, which are quiescent and respond quickly to antigens upon recall.
Step 5: When the B cells are activated, some B cells turn into plasma cells and are released in the blood, while other B cells become B memory cells that quicken response for a second exposure. Step 6: Plasma cells then secrete antibodies, which bind to antigens to fight the invading pathogens.
B cell activation: from immature B cell to plasma cell or memory B cell Basic B cell function: bind to an antigen, receive help from a cognate helper T cell, and differentiate into a plasma cell that secretes large numbers of antibodies. B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. [1]
In immunology, a naive B cell is a B cell that has not been exposed to an antigen. These are located in the tonsils , spleen , and primary lymphoid follicles in lymph nodes . Once exposed to an antigen , the naive B cell either becomes a memory B cell or a plasma cell that secretes antibodies specific to the antigen that was originally bound.
As the activated B cell then begins to divide, its offspring (plasma cells) secrete millions of copies of the antibody that recognizes this antigen. These antibodies circulate in blood plasma and lymph, bind to pathogens expressing the antigen and mark them for destruction by complement activation or for uptake and destruction by phagocytes ...
M cells play a role in passive immunity, or the transfer of active humoral immunity during and post pregnancy. Infants rely on antibodies specific to their mother's intestinal antigens, which move from the mother's gut and enter the breast milk. These antibodies are able to move into the milk supply through the lymphatic system. Even though the ...