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A demyelinating disease is a condition that causes a damage to the myelin in your brain, spinal cord and nerves. Myelin is a protective cover (sheath) around the body section (axon) of nerve cells (neurons) in your central and peripheral nervous system.
Peripheral neuropathy, a common neurologic problem encountered by family physicians, can be classified clinically by the anatomic pattern of presenting symptoms and, if indicated, by results of...
A demyelinating disease is any condition that causes damage to the protective covering that surrounds nerve fibers. This covering is called the myelin sheath. In the central nervous system, the myelin sheath protects nerves in the brain, spinal cord and nerves leading to the eyes, known as optic nerves.
The peripheral neuropathy associated with POEMS syndrome is typically a uniform mixed demyelinating and axonal length-independent polyradiculoneuropathy in the setting of an IgG or IgA paraproteinemia with a λ light chain. 41 POEMS syndrome is associated with osteosclerotic myeloma and increased levels of serum vascular endothelial growth factor.
Giant axonal neuropathy (GAN), which happens when the GAN1 gene is changed and causes the axons, or the message sender of the nerve cell, to become larger than normal and eventually break down, causing movement and sensation problems. GAN is progressive, meaning that it worsens over time.
Segmental Demyelination. Segmental demyelination refers to the degeneration of the myelin sheath, with sparing of the nerve axon. This type of reaction can present in mononeuropathies, sensorimotor, or, principally, motor neuropathies. These are often inflammatory and sometimes immune-mediated.
Electrodiagnostic studies, including nerve conduction studies and electro-myography, can help in the differentiation of axonal versus demyelinating or mixed neuropathy. Treatment should address...
Peripheral neuropathy refers to any condition that affects the nerves outside your brain or spinal cord. This can happen for several reasons, from trauma to infections to inherited conditions. There are also many possible symptoms. Many causes, forms or symptoms of this condition are treatable, but this can vary widely from person to person.
Electrodiagnostic (EDX) testing can be performed to understand the etiology, severity, prognosis, and possible treatment options for peripheral neuropathy. It can identify the primary characteristics of the neuropathy as axonal, demyelinating, sensory, motor, multifocal, or diffuse; however, there is often overlap.
Sensory neuropathies refer to a host of diseases that result in loss of sensation throughout the body. Collectively, sensory neuropathies can result from a plethora of conditions. These sensory neuropathies may be subdivided into small fiber pain-dominant and large fiber ataxia-predominant pathologies.