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Teratology. Phocomelia is a congenital condition that involves malformations of human arms and legs which result in a flipper-like appendage. [ 1 ][ 2 ] A prominent cause of phocomelia is the mother being prescribed the use of the drug thalidomide during pregnancy; however, the causes of most cases are to be determined. [ 2 ]
Rh disease. Rh disease (also known as rhesus isoimmunization, Rh (D) disease, or rhesus incompatibility, and blue baby disease) is a type of hemolytic disease of the fetus and newborn (HDFN). HDFN due to anti-D antibodies is the proper and currently used name for this disease as the Rh blood group system actually has more than 50 antigens and ...
George Douglas, the Earl of Morton. Sarah Biffen (1784 – 2 October 1850), also known as Sarah Biffin, Sarah Beffin, [1] or by her married name Mrs E. M. Wright, [2] was an English painter born with no arms and only vestigial legs. She was born in 1784 in Somerset. [3] Despite her disability she learned to read and write, and to paint using ...
Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries by women who were pregnant or who subsequently became pregnant resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as phocomelia, as well as thousands of ...
Specialty. Medical genetics. Amelia is the birth defect of lacking one or more limbs. [1][2] The term may be modified to indicate the number of legs or arms missing at birth, such as tetra-amelia for the absence of all four limbs. The term is from Ancient Greek ἀ- 'lack of' and μέλος 'limb'.
Vos originally described Rh-deficiency syndrome in 1961, when a sample of blood failed to respond with several Rh antisera. However, R. Ceppellini used the term "Rhnull" for the first time. So far, at least 43 people from 14 families have been reported in the literature as having the Rhnull phenotype.
The Rh blood group system is a human blood group system. It contains proteins on the surface of red blood cells. After the ABO blood group system, it is the most likely to be involved in transfusion reactions. The Rh blood group system consisted of 49 defined blood group antigens [1] in 2005. As of 2023, there are over 50 antigens among which ...
Ruth Renter Darrow (1895–1956) was an American pathologist [2] who was the first to identify the cause of hemolytic disease of the newborn (HDN). [3] [4] [5] In 1938, three years prior to the discovery of antibodies against the Rh antigen, [4] Darrow correctly hypothesized that the disease was caused by destruction of red blood cells due to antibodies in the mother's blood. [3]