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Hydroxyproline and proline play key roles for collagen stability. [4] They permit the sharp twisting of the collagen helix. [ 5 ] In the canonical collagen Xaa-Yaa-Gly triad (where Xaa and Yaa are any amino acid), a proline occupying the Yaa position is hydroxylated to give a Xaa-Hyp-Gly sequence.
In 1954, Ramachandran & Kartha (13, 14) advanced a structure for the collagen triple helix on the basis of fiber diffraction data. It consists of a triple helix made of the repetitious amino acid sequence glycine-X-Y, where X and Y are frequently proline or hydroxyproline. [2] [3] Collagen folded into a triple helix is known as tropocollagen.
Furthermore, proline is rarely found in α and β structures as it would reduce the stability of such structures, because its side chain α-nitrogen can only form one nitrogen bond. Additionally, proline is the only amino acid that does not form a red-purple colour when developed by spraying with ninhydrin for uses in chromatography. Proline ...
This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase that catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia , an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5 ...
Pet cats have their own little quirks, one being the ability to slip into the most unusual places around the house. Before you know it, you’re finding your furry feline friend balled up in a ...
The cast of “Friends” is well known for being besties, but that developed over time. During an appearance on Dax Shepard’s “Armchair Expert” podcast, “Friends” star Lisa Kudrow ...
Soon after Kay took on a new role at an e-commerce company in the fall of 2023, the responsibilities began to pile up.. Kay – who asked USA TODAY to not use her full name for fear of losing her ...
Retrieved from "https://en.wikipedia.org/w/index.php?title=Hydroxylated_proline&oldid=955085771"This page was last edited on 5 May 2020, at 22:03 (UTC) (UTC)
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