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In genetics, the coefficient of coincidence (c.o.c.) is a measure of interference in the formation of chromosomal crossovers during meiosis. It is generally the case that, if there is a crossover at one spot on a chromosome, this decreases the likelihood of a crossover in a nearby spot. [1] This is called interference.
The Kosambi mapping function was introduced to account for the impact played by crossover interference on recombination frequency. It introduces a parameter C, representing the coefficient of coincidence, and sets it equal to 2r. For loci which are strongly linked, interference is strong; otherwise, interference decreases towards zero. [5]
Crossover interference is the term used to refer to the non-random placement of crossovers with respect to each other during meiosis.The term is attributed to Hermann Joseph Muller, who observed that one crossover "interferes with the coincident occurrence of another crossing over in the same pair of chromosomes, and I have accordingly termed this phenomenon ‘interference’."
There are two popular and overlapping theories that explain the origins of crossing-over, coming from the different theories on the origin of meiosis.The first theory rests upon the idea that meiosis evolved as another method of DNA repair, and thus crossing-over is a novel way to replace possibly damaged sections of DNA. [9]
In population genetics, the Hill–Robertson effect, or Hill–Robertson interference, is a phenomenon first identified by Bill Hill and Alan Robertson in 1966. [1] It provides an explanation as to why there may be an evolutionary advantage to genetic recombination .
Luck. Fate. Blessing. A glitch in the matrix. Or, if you’re more skeptical, just a coincidence.. It’s a phenomenon that, from a statistical perspective, is random and meaningless.
The problem is that the term “gene” has been used since the foundation of genetics without a clear understanding of what a gene actually is. So, despite its widespread popular usage, its use is now avoided in genetics journals (see [3] for a discussion about the changing definition of the gene). This is unfortunate for discussions of ...
Getting enough rest gives your body time to repair and grow stronger, while carbs, omega-3s, and other key nutrients may help fuel your workouts and recovery, according to a 2024 study published ...