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Cefuroxime, sold under the brand name Zinacef among others, is a second-generation cephalosporin [3] antibiotic used to treat and prevent a number of bacterial infections. [4] These include pneumonia , meningitis , otitis media , sepsis , urinary tract infections , and Lyme disease . [ 5 ]
Cefuroxime axetil, sold under the brand name Ceftin among others, is a second generation oral cephalosporin antibiotic. It is an acetoxyethyl ester prodrug of cefuroxime which is effective orally. [2] The activity depends on in vivo hydrolysis and release of cefuroxime tablets. [citation needed] It was patented in 1976 and approved for medical ...
Researchers have developed antibiotics that include cephems and they have tried to test them clinically. [5] Many of the antibiotics that are manufactured have different efficiencies based on the amount used, their strength, and their antibacterial spectra. [5]
Cefotiam is a parenteral third-generation cephalosporin antibiotic.It has broad-spectrum activity against Gram-positive and Gram-negative bacteria. As a beta-lactam, its bactericidal activity results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins.
Further modification of this drug by inclusion of a quaternary ammonium cation gives a compound suitable for parenteral administration by increasing water solubility. The acid in cefotaxime is first protected as its silyl ester ( 2 ) by derivatization with N -methyl- N -(trimethylsilyl)trifluoroacetamide ( MSTFA ).
Luigi Mangione, the man accused of fatally shooting UnitedHealthcare CEO Brian Thompson earlier this month, is facing upgraded murder charges in New York, officials announced on Tuesday. Mangione ...
Dolatshahi went on to note that “lifestyle factors like diet and physical activity can affect the body fat distribution and the recently approved anti-obesity drugs are recognized to have ...
Studies indicate that the mechanism by which a drug or its metabolites accomplishes this stimulation involves subverting the antigen presentation pathways of the innate immune system. A drug or metabolite covalently binds with a host protein to form a non-self, drug-related epitope.