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Topical 5-fluorouracil (5-FU, Efudex, Carac) has been shown to be an effective therapy for diffuse, but minor actinic cheilitis. 5-fluorouracil works by blocking DNA synthesis. Cells that are rapidly growing need more DNA, so they accumulate more 5-fluorouracil, resulting in their death. Normal skin is much less affected.
Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
The underlying cancer is most often gastric adenocarcinoma [1]: 63 [2] [3] but also with breast cancer, bladder cancer, hepatobiliary cancer, ovarian cancer, uterine cancer, [4] prostate cancer [citation needed], lung cancer [5] and cervical cancer. [6] Other associated underlying malignancies include squamous cell carcinomas and lymphomas. [7]
Topical creams, such as 5-fluorouracil or imiquimod, may require daily application to affected skin areas over a typical time course of weeks. [ 13 ] Cryotherapy is frequently used for few and well-defined lesions, [ 14 ] but undesired skin lightening, or hypopigmentation, may occur at the treatment site. [ 15 ]
If there is a persistent sore that does not heal or a growing lump within the rash, a skin biopsy should be performed to rule out the possibility of skin cancer. If the erythema ab igne lesions demonstrate pre-cancerous changes, the use of 5-fluorouracil cream has been recommended.
Cutaneous squamous-cell carcinoma (cSCC), also known as squamous-cell carcinoma of the skin or squamous-cell skin cancer, is one of the three principal types of skin cancer, alongside basal-cell carcinoma and melanoma. [10] cSCC typically presents as a hard lump with a scaly surface, though it may also present as an ulcer. [1]
MADRID (AP) — Kylian Mbappé made some peace with Real Madrid’s fans. Mbappé scored in Madrid's 2-0 win over Getafe in the Spanish league on Sunday to help ease the pressure on the France star.
Fluorodeoxyuridylate, [1] also known as FdUMP, 5-fluoro-2'-deoxyuridylate, and 5-fluoro-2'-deoxyuridine 5'-monophosphate, is a molecule formed in vivo from 5-fluorouracil and 5-fluorodeoxyuridine. FdUMP acts as a suicide inhibitor of thymidylate synthase (TS). By inhibiting the deoxynucleotide biosynthesis, FdUMP stops the rapidly proliferation ...
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