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Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid and haematological malignancies. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g., small cell lung cancer, squamous cell carcinoma of the head and neck and ovarian cancer), lymphomas, bladder cancer, cervical cancer, [9] and germ cell tumors.
IV infusion: Day 0 Dexamethasone: 40 mg: PO qd: Days 1-4 High-dose Ara-C - cytarabine: 2000 mg/m 2: IV infusion over 2 hrs: Day 2, every 12 hours Platinol (cisplatin) 100 mg/m 2: IV infusion over 24 hrs: Day 1
IV infusion: Day 0 Etoposide: 40 mg/m 2: IV infusion over 1 hr: Days 1-4 Solu-Medrol - Methylprednisolone: 500 mg: IV bolus over 15 min: Days 1-5 High-dose Ara-C — cytarabine: 2000 mg/m 2: IV infusion over 2 hrs: Day 5 Platinol (cisplatin) 25 mg/m 2: IV continuous infusion over 24 hrs: Days 1-4
Cisplatin and derivatives include cisplatin, carboplatin and oxaliplatin. [37] [38] They impair cell function by forming covalent bonds with the amino, carboxyl, sulfhydryl, and phosphate groups in biologically important molecules. [41] Non-classical alkylating agents include procarbazine and hexamethylmelamine. [37] [38]
This is a list of chemotherapeutic agents, also known as cytotoxic agents or cytostatic drugs, that are known to be of use in chemotherapy for cancer.This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision.
Cisplatin was the first to be developed. [9] Cisplatin is particularly effective against testicular cancer; the cure rate was improved from 10% to 85%. [10] Similarly, the addition of cisplatin to adjuvant chemotherapy led to a marked increase in disease-free survival rates for patients with medulloblastoma - again, up to around 85%.
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a type of hyperthermia therapy used in combination with surgery in the treatment of advanced abdominal cancers. [1] In this procedure, warmed anti-cancer medications are infused and circulated in the peritoneal cavity (abdomen) for a short period of time.
photo showing chemotherapy with chemo infusion. High-dose chemotherapy (HDC) is a regimen of chemotherapy medicines given at larger dosages. This therapeutic strategy is used to treat some cancers, especially those that are aggressive or have a high chance of coming back.