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Tolvaptan, sold under the brand name Samsca among others, is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 (V 2) antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
Tolvaptan phosphate is a drug used for the treatment of cardiac edema. It is a prodrug of tolvaptan, [1] [2] formulated as the salt tolvaptan sodium phosphate, for intravenous administration. Tolvaptan phosphate is converted into the active drug tolvaptan in the human body following administration.
More and more people are talking about polyphasic sleep patterns. But a sleep doctor explains why polyphasic sleep is so unhealthy for humans.
Tolvaptan is a racemic small molecule drug (Molecular Weight of 448.9 g.mol-1) and is a lipophilic drug, is essentially insoluble in water, and has fair oral absorption (>40% bioavailable). Tolvaptan hsa a plasma half-life of around 12 hours, a volume of distribution of 3L/kg, and has high plasma protein binding at 99%.
There’s reason to be a bit wary about popping a gummy to see if it does work. Dr. Mickey Karram , a gynecologist and urogynecologist, notes that supplements in general are not regulated by the ...
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Keira Knightley, 39, stars in Netflix's new spy thriller 'Black Doves.' Here's how she trained for the series, plus all the details on her workouts and diet.