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Dextromethorphan, or DXM, a common active ingredient found in many over-the-counter cough suppressant cold medicines, is used as a recreational drug and entheogen for its dissociative effects. [1] Street names include Brownies , Dextro , Drix , Gel , Groove , Lean , Mega-perls , Poor man's ecstasy , Poor man's PCP, Red devils , Robo , Rojo ...
Dextromethorphan does not have a significant affinity for the mu-opioid receptor activity typical of morphinan compounds and exerts its therapeutic effects through several other receptors. [8] In its pure form, dextromethorphan occurs as a white powder. [9] When exceeding approved dosages, dextromethorphan acts as a dissociative hallucinogen.
Side effects of dextromethorphan/bupropion include dizziness, headache, diarrhea, somnolence, dry mouth, sexual dysfunction, and hyperhidrosis, among others. [1] The mechanism of action of dextromethorphan/bupropion in the treatment of depression is unknown. [1]
Dextromethorphan, also shortened to DXM, affects the NMDA receptor and serotonin receptors which is believed to give its psychoactive effects at high doses. Similarly to codeine, DXM comes primarily in formulations that contain other OTC medications and is not common to find DXM on its own.
Dextrorphan is produced by O-demethylation of dextromethorphan by CYP2D6. Dextrorphan is an NMDA antagonist and contributes to the psychoactive effects of dextromethorphan. [ 2 ]
Laxatives are designed for constipation, not weight loss, and can lead to serious side effects and dangerous complications when used incorrectly. When you lose weight on laxatives, it's from water ...
Dextromethorphan for its part is widely used as a cough medication, but its other actions have led to trials for several conditions such as its use as an adjunct to analgesia, and a potential anti-addictive drug, as well as its occasional recreational use as a dissociative. [citation needed]
Methorphan comes in two isomeric forms, each with differing pharmacology and effects: Dextromethorphan – An over-the-counter cough suppressant, as well as dissociative hallucinogen. Levomethorphan – A potent opioid analgesic that was never clinically developed; a prodrug of the powerful opioid agonist analgesic levorphanol (Levo-Dromoran).