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Chromium supplementation in general is subject to a certain amount of controversy as it is by no means clear that chromium is an essential element in human biology. [25] Nevertheless, chromium is an ingredient in total parenteral nutrition, along with other trace minerals. [26] It is also in nutritional products for preterm infants. [27]
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Trace metals within the human body include iron, lithium, zinc, copper, chromium, nickel, cobalt, vanadium, molybdenum, manganese and others. [1] [2] [3] Some of the trace metals are needed by living organisms to function properly and are depleted through the expenditure of energy by various metabolic processes of living organisms.
Mineral deficiency is a lack of the dietary minerals, the micronutrients that are needed for an organism's proper health. [1] The cause may be a poor diet , impaired uptake of the minerals that are consumed, or a dysfunction in the organism's use of the mineral after it is absorbed.
For example, whether chromium is essential in humans is debated. No Cr-containing biochemical has been purified. The United States and Japan designate chromium as an essential nutrient, [11] [12] but the European Food Safety Authority (EFSA), representing the European Union, reviewed the question in 2014 and does not agree. [13]
Chromium is an ingredient in total parenteral nutrition (TPN), because deficiency can occur after months of intravenous feeding with chromium-free TPN. [121] It is also added to nutritional products for preterm infants . [ 122 ]
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Hexavalent chromium and trivalent chromium are chromium ions—they have different numbers of electrons and, therefore, different properties. Trivalent chromium, or chromium(III), is the form of chromium that is essential to human health. [3] Hexavalent chromium, or chromium(VI), is an unequivocally toxic form.